FOR TRAUMA SURGEONS

Support Regeneration.

A targeted perioperative nutritional protocol to combat hypermetabolism, preserve lean mass, and support massive tissue regeneration in trauma surgery.

The Clinical Challenge

Polytrauma and major orthopaedic trauma induce a severe, prolonged hypermetabolic and catabolic state. The body rapidly breaks down skeletal muscle to fuel the massive immune and regenerative response.1

1.5
kg of lean muscle mass can be lost per week during critical illness and major trauma.2
3X
greater muscle protein synthesis with leucine-enriched EAAs vs intact protein.3

This profound muscle degradation compromises respiratory function, delays mobilisation, and significantly extends the rehabilitation timeline. For the patient, this translates to devastating weakness and loss of independence.4

Combating Hypermetabolism

Surgical trauma induces severe anabolic resistance. Standard dietary protein is insufficient to overcome this. High-dose, leucine-enriched EAAs are required to support mTORC1 pathway activity, providing the critical substrates needed for massive tissue regeneration.5

The Rebound Protocol

Rebound is a physician-formulated, three-phase perioperative nutrition protocol designed to optimise surgical outcomes and accelerate patient recovery in trauma surgery.

Rebound READY (Pre-op)

Provides metabolic stabilization post-injury or pre-fixation, attenuating further insulin resistance and preserving remaining glycogen stores.1,2

Rebound RECOVER (Post-op)

Delivers a high-leucine EAA complex to support mTORC1 signalling, providing the massive influx of anabolic substrates required to combat hypermetabolic catabolism.3,4

Rebound RESTORE (Healing)

Supplies essential micronutrients (Vitamin D, Calcium, Zinc, Vitamin C) critical for fracture callus formation and extensive wound healing.5

Clinical Integration

Rebound integrates into trauma recovery protocols. The EAA complex (Recover) provides a powerful anabolic trigger, while the Restore phase provides the biological building blocks necessary for structural integrity.6

By mitigating surgical stress and delivering precise anabolic amino acids, Rebound supports patients to engage more effectively in early physical therapy, driving better functional outcomes.

Clinical Evidence

  1. Hendrickson NR, Davison J, Glass NA, et al. Conditionally Essential Amino Acid Supplementation Reduces Postoperative Complications and Muscle Wasting After Fracture Fixation: A Randomized Controlled Trial. J Bone Joint Surg Am. 2022;104(9):759-766. doi:10.2106/JBJS.21.01014.
  2. Aquilani R, Zuccarelli Ginetto C, Rutili C, et al. Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery. Aging Clin Exp Res. 2019;31:157-160. doi:10.1007/s40520-018-0941-x.
  3. Wolfe RR. The 2017 Sir David P Cuthbertson lecture. Amino acids and muscle protein metabolism in critical care. Clin Nutr. 2018;37(4):1093-1100. doi:10.1016/j.clnu.2017.12.010.
  4. Cai Y, Kang F, Wang X. Critical illness and bone metabolism: where are we now and what is next? Eur J Med Res. 2022;27:177. doi:10.1186/s40001-022-00805-w.
  5. Huang L, Zhu L, Zhao Z, Jiang S. Hyperactive browning and hypermetabolism: potentially dangerous element in critical illness. Front Endocrinol (Lausanne). 2024;15:1484524. doi:10.3389/fendo.2024.1484524.
  6. Corsetti G, Pasini E. Amino Acids as Metabokines in Hypercatabolic States: Rethinking Nutritional Protein-Based Strategies Beyond Caloric Support. Nutrients. 2026;18(11):1703. doi:10.3390/nu18111703.
READY • RECOVER • RESTORE • THRIVE